Prions : The Infectious Protein Agent :: Biology Mad Cow Creutzfeldt Jakob Disease

wanting(p) graphs What causes Mad Cow Disease? Prions. Prions atomic number 18 also behind otherwisewise neurodegenerative infirmitys such as the Creutzfeldt-Jakob disease, Kuru, Gerstmann-Straussler-Scheinker disease and some forms of fatal insomnia. These are tout ensemble prions diseases that have been found to exist in humans. The prion disease for cattle is what we enjoy as the Mad Cow Disease. Prions also exist in other animals such as sheep, mink, mule deer, elk, cats, and some others.So whats so supererogatory about prions? impertinent other neurodegenerative diseases that are caused by the misfolding of proteins, altered proteins, antidromic gene splicing, improper expression, or ineffective clearing of proteins which slowly leads to disease by accumulation, prions cause disease by acting as an morbific agent. One abnormal prion protein is enough to turn all the normal prion proteins attest into itself.How do prions do that? Scientists are still unsure of how exa ctly wholeness protein is capable of turning another protein into itself. Many experiments are conducted to help fox light on its mysterious capabilities. In this website, we hope to explain genius of these experiments that involved the effect of pH on the structure of prion proteins.Wait...Prions? Prion Protein? Which is which? Prions is the name charge to infectious protein agents. Prion protein (PrPC) is the normal cellular protein that can become an infectious agent. The formalised Mad Cow Disease Home Page The prion is a impertinently discovered pathogen that is vastly disaccordent from the known pathogens of today namely viruses and bacteria. Unlike the bacteria, no antibiotics can cure prions. They are not typical of a prokaryotic organism or a eukaryotic organism, all that is defer in this pathogen is the protein PrPSc. This is the mutated form of the protein PrPC, which is encoded by a chromosomal gene. These two proteins differ in their spatial protein structures a nd their susceptibility to enzyme digestion. PrPC is completely destroyed in enzyme digestion, whereas PrPSc is skanky to any form of digestion.Viruses usually have nucleic acid, protein, and other constituents that aid in the creation of more progeny viruses. As far as prions are concerned, they multiply by infecting the PrPC protein and turning it into a complex such as itself, the PrPSc protein. Prions exist in multiple molecular forms whereas viruses exist in a single form with distinct ultrastructural morphology.Another difference between the virus and the prion is that viruses roughly always provoke an immune response in the host that it is infecting.